Mackie has had a distinguished academic career, gaining an MD (1970), and DSc in 1994. In 1983 she became a Fellow of the Royal Society of Edinburgh and in1998, she was a Founding Fellow of the Academy of Medical Sciences. The British Association of Dermatologists awarded her the Archibald Grey Gold Medal in 1999.

Mackie’s work on melanoma has been highly received across the world, and in the field of transplantation has influenced practice with former melanoma patients in Europe and North America.